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KMID : 0617319910010010026
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Journal of Pharmacetical Sceiences Ewha Womans University
1991 Volume.1 No. 1 p.26 ~ p.31
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Synthesis of Quinazoline 4-one Derivatives from 2-Aminobenzamide (Ⅲ)
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Abstract
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The reaction of 2-aminobenzamide with phthalic acid anhydride In dioxane produced a bicyclic product 2,8-dioxoisoindole(1.2.a) quinazoline (1) in addition to hydrolysis product 2(2-Carboxyphenyl)-1.2-2H-quinazoline-4-one(Ⅱ).
The yields were 64% and 30% respectively. On the other hand, the same reaction in DMF afforded compound(Ⅰ) and 2(2N-dimethyl carbamyl phenyl)-1.4-2H-quinazoline-4-one(Ⅲ) in 30% and 60% yield respectively. The compound Ⅲ was also obtained by the reaction of compoundⅡ with dimethylamine. However the reaction of 2-aminobenzamide with neat succinic acid anhydride gave only bicycle product 2.8-oxopyrrolidine (2.1.a)-1.4-2H-quinazoline (Ⅳ) in 93%.
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